GNL3-MANF Fusion FISH Probe
The GNL3-MANF Fusion FISH Probe is used to confirm a fusion of the GNL3 and MANF genes. The fusion of the GNL3 and MANF genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNL3-MANF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-RERE | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-REOR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-REGO | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-REGR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-REAQ | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-ORRE | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-OROR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-ORGO | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GORE | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GOOR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GOGO | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GOGR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GRRE | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GROR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GRGO | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GRGR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-AQRE | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-AQOR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-AQGO | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-AQGR | 20 (40 μL) | 200 μL |
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| GNL3-MANF-20-AQAQ | 20 (40 μL) | 200 μL |
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MANF Gene Summary
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
Gene Name: Mesencephalic Astrocyte Derived Neurotrophic Factor
Chromosome: CHR3: 51422691 -51426828
Locus: 3p21.2
GNL3 Gene Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: G Protein Nucleolar 3
Chromosome: CHR3: 52719935 -52728510
Locus: 3p21.1
Gene Diseases
The GNL3 MANF Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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