GNL3-CLCN3 Fusion FISH Probe
The GNL3-CLCN3 Fusion FISH Probe is used to confirm a fusion of the GNL3 and CLCN3 genes. The fusion of the GNL3 and CLCN3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNL3-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| GNL3-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
GNL3 Gene Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: G Protein Nucleolar 3
Chromosome: CHR3: 52719935 -52728510
Locus: 3p21.1
Gene Diseases
The GNL3 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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