GNL3-BAP1 Fusion FISH Probe
The GNL3-BAP1 Fusion FISH Probe is used to confirm a fusion of the GNL3 and BAP1 genes. The fusion of the GNL3 and BAP1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNL3-BAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-RERE | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-REOR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-REGO | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-REGR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-OROR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GORE | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GROR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| GNL3-BAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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BAP1 Gene Summary
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Gene Name: BRCA1 Associated Protein 1
Chromosome: CHR3: 52435024 -52444009
Locus: 3p21.1
GNL3 Gene Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: G Protein Nucleolar 3
Chromosome: CHR3: 52719935 -52728510
Locus: 3p21.1
Gene Diseases
The GNL3 BAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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