GNB1L-TXNRD2 Fusion FISH Probe
The GNB1L-TXNRD2 Fusion FISH Probe is used to confirm a fusion of the GNB1L and TXNRD2 genes. The fusion of the GNB1L and TXNRD2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNB1L-TXNRD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-RERE | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-REOR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-REGO | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-REGR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-REAQ | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-ORRE | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-OROR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-ORGO | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GORE | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GOOR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GOGO | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GOGR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GRRE | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GROR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GRGO | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GRGR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-AQRE | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-AQOR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-AQGO | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-AQGR | 20 (40 μL) | 200 μL |
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| GNB1L-TXNRD2-20-AQAQ | 20 (40 μL) | 200 μL |
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TXNRD2 Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Thioredoxin Reductase 2
Chromosome: CHR22: 19863039 -19929359
Locus: 22q11.21
GNB1L Gene Summary
This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
Gene Name: G Protein Subunit Beta 1 Like
Chromosome: CHR22: 19775933 -19842462
Locus: 22q11.21
Gene Diseases
The GNB1L TXNRD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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