GNAS-SUPT16H Fusion FISH Probe
The GNAS-SUPT16H Fusion FISH Probe is used to confirm a fusion of the GNAS and SUPT16H genes. The fusion of the GNAS and SUPT16H genes has been associated with Lung Squamous Cell Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GNAS-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| GNAS-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
|
GNAS Gene Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Name: GNAS Complex Locus
Chromosome: CHR20: 57414794 -57486250
Locus: 20q13.32
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The GNAS SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|