GNAS-SEC63 Fusion FISH Probe
The GNAS-SEC63 Fusion FISH Probe is used to confirm a fusion of the GNAS and SEC63 genes. The fusion of the GNAS and SEC63 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNAS-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| GNAS-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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GNAS Gene Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Name: GNAS Complex Locus
Chromosome: CHR20: 57414794 -57486250
Locus: 20q13.32
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The GNAS SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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