GNAS-PLXNC1 Fusion FISH Probe
The GNAS-PLXNC1 Fusion FISH Probe is used to confirm a fusion of the GNAS and PLXNC1 genes. The fusion of the GNAS and PLXNC1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNAS-PLXNC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-RERE | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-REOR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-REGO | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-REGR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-REAQ | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-ORRE | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-OROR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-ORGO | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GORE | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GOOR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GOGO | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GOGR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GRRE | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GROR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GRGO | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GRGR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-AQRE | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-AQOR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-AQGO | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-AQGR | 20 (40 μL) | 200 μL |
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| GNAS-PLXNC1-20-AQAQ | 20 (40 μL) | 200 μL |
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GNAS Gene Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Name: GNAS Complex Locus
Chromosome: CHR20: 57414794 -57486250
Locus: 20q13.32
PLXNC1 Gene Summary
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Plexin C1
Chromosome: CHR12: 94542498 -94701451
Locus: 12q22
Gene Diseases
The GNAS PLXNC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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