GNAS-FOXP1 Fusion FISH Probe
The GNAS-FOXP1 Fusion FISH Probe is used to confirm a fusion of the GNAS and FOXP1 genes. The fusion of the GNAS and FOXP1 genes has been associated with Kidney Chromophobe, and Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNAS-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| GNAS-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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GNAS Gene Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Name: GNAS Complex Locus
Chromosome: CHR20: 57414794 -57486250
Locus: 20q13.32
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The GNAS FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Chromophobe |
| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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