GNA14-TNFSF8 Fusion FISH Probe
The GNA14-TNFSF8 Fusion FISH Probe is used to confirm a fusion of the GNA14 and TNFSF8 genes. The fusion of the GNA14 and TNFSF8 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNA14-TNFSF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-RERE | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-REOR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-REGO | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-REGR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-REAQ | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-ORRE | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-OROR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-ORGO | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GORE | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GOOR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GOGO | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GOGR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GRRE | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GROR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GRGO | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GRGR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-AQRE | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-AQOR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-AQGO | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-AQGR | 20 (40 μL) | 200 μL |
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| GNA14-TNFSF8-20-AQAQ | 20 (40 μL) | 200 μL |
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TNFSF8 Gene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: TNF Superfamily Member 8
Chromosome: CHR9: 117665123 -117692770
Locus: 9q32-q33.1
GNA14 Gene Summary
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Gene Name: G Protein Subunit Alpha 14
Chromosome: CHR9: 80037994 -80263232
Locus: 9q21.2
Gene Diseases
The GNA14 TNFSF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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