GMDS-VAPB Fusion FISH Probe
The GMDS-VAPB Fusion FISH Probe is used to confirm a fusion of the GMDS and VAPB genes. The fusion of the GMDS and VAPB genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMDS-VAPB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-RERE | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-REOR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-REGO | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-REGR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-REAQ | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-ORRE | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-OROR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-ORGO | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GORE | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GOOR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GOGO | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GOGR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GRRE | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GROR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GRGO | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GRGR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-AQRE | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-AQOR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-AQGO | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-AQGR | 20 (40 μL) | 200 μL |
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| GMDS-VAPB-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
VAPB Gene Summary
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Gene Name: VAMP Associated Protein B And C
Chromosome: CHR20: 56964174 -57026156
Locus: 20q13.32
Gene Diseases
The GMDS VAPB Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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