GMDS-TMTC2 Fusion FISH Probe
The GMDS-TMTC2 Fusion FISH Probe is used to confirm a fusion of the GMDS and TMTC2 genes. The fusion of the GMDS and TMTC2 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMDS-TMTC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-RERE | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-REOR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-REGO | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-REGR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-REAQ | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-ORRE | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-OROR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-ORGO | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GORE | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GOOR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GOGO | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GOGR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GRRE | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GROR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GRGO | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GRGR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-AQRE | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-AQOR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-AQGO | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-AQGR | 20 (40 μL) | 200 μL |
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| GMDS-TMTC2-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
TMTC2 Gene Summary
The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Transmembrane And Tetratricopeptide Repeat Containing 2
Chromosome: CHR12: 83080933 -83528067
Locus: 12q21.31
Gene Diseases
The GMDS TMTC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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