GMDS-PPP1R11 Fusion FISH Probe
The GMDS-PPP1R11 Fusion FISH Probe is used to confirm a fusion of the GMDS and PPP1R11 genes. The fusion of the GMDS and PPP1R11 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMDS-PPP1R11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-RERE | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-REOR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-REGO | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-REGR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-REAQ | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-ORRE | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-OROR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-ORGO | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GORE | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GOOR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GOGO | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GOGR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GRRE | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GROR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GRGO | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GRGR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-AQRE | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-AQOR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-AQGO | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-AQGR | 20 (40 μL) | 200 μL |
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| GMDS-PPP1R11-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
PPP1R11 Gene Summary
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Regulatory Inhibitor Subunit 11
Chromosome: CHR6_mann_hap4: 1333523 -1336701
Locus: 6p22.1
Gene Diseases
The GMDS PPP1R11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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