GMDS-MRPS18B Fusion FISH Probe
The GMDS-MRPS18B Fusion FISH Probe is used to confirm a fusion of the GMDS and MRPS18B genes. The fusion of the GMDS and MRPS18B genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMDS-MRPS18B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-RERE | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-REOR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-REGO | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-REGR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-REAQ | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-ORRE | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-OROR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-ORGO | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GORE | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GOOR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GOGO | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GOGR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GRRE | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GROR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GRGO | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GRGR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-AQRE | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-AQOR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-AQGO | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-AQGR | 20 (40 μL) | 200 μL |
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| GMDS-MRPS18B-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
MRPS18B Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S18B
Chromosome: CHR6_dbb_hap3: 1879123 -1887812
Locus: 6p21.33
Gene Diseases
The GMDS MRPS18B Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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