GMCL1-DYSF Fusion FISH Probe
The GMCL1-DYSF Fusion FISH Probe is used to confirm a fusion of the GMCL1 and DYSF genes. The fusion of the GMCL1 and DYSF genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMCL1-DYSF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-RERE | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-REOR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-REGO | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-REGR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-REAQ | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-ORRE | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-OROR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-ORGO | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GORE | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GOOR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GOGO | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GOGR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GRRE | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GROR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GRGO | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GRGR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-AQRE | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-AQOR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-AQGO | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-AQGR | 20 (40 μL) | 200 μL |
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| GMCL1-DYSF-20-AQAQ | 20 (40 μL) | 200 μL |
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DYSF Gene Summary
The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]
Gene Name: Dysferlin
Chromosome: CHR2: 71680752 -71913893
Locus: 2p13.2
GMCL1 Gene Summary
This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]
Gene Name: Germ Cell-less, Spermatogenesis Associated 1
Chromosome: CHR2: 70056817 -70106727
Locus: 2p13.3
Gene Diseases
The GMCL1 DYSF Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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