GLUL-SEC63 Fusion FISH Probe
The GLUL-SEC63 Fusion FISH Probe is used to confirm a fusion of the GLUL and SEC63 genes. The fusion of the GLUL and SEC63 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLUL-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| GLUL-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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GLUL Gene Summary
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Glutamate-ammonia Ligase
Chromosome: CHR1: 182350838 -182361341
Locus: 1q25.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The GLUL SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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