GLI3-PGC Fusion FISH Probe
The GLI3-PGC Fusion FISH Probe is used to confirm a fusion of the GLI3 and PGC genes. The fusion of the GLI3 and PGC genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLI3-PGC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-RERE | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-REOR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-REGO | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-REGR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-REAQ | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-ORRE | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-OROR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-ORGO | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GORE | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GOOR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GOGO | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GOGR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GRRE | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GROR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GRGO | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GRGR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-AQRE | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-AQOR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-AQGO | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-AQGR | 20 (40 μL) | 200 μL |
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| GLI3-PGC-20-AQAQ | 20 (40 μL) | 200 μL |
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GLI3 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Name: GLI Family Zinc Finger 3
Chromosome: CHR7: 42000547 -42276618
Locus: 7p14.1
PGC Gene Summary
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Gene Name: Progastricsin
Chromosome: CHR6: 41704448 -41715139
Locus: 6p21.1
Gene Diseases
The GLI3 PGC Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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