GLI3-CROT Fusion FISH Probe
The GLI3-CROT Fusion FISH Probe is used to confirm a fusion of the GLI3 and CROT genes. The fusion of the GLI3 and CROT genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLI3-CROT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-RERE | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-REOR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-REGO | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-REGR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-REAQ | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-ORRE | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-OROR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-ORGO | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GORE | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GOOR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GOGO | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GOGR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GRRE | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GROR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GRGO | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GRGR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-AQRE | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-AQOR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-AQGO | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-AQGR | 20 (40 μL) | 200 μL |
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| GLI3-CROT-20-AQAQ | 20 (40 μL) | 200 μL |
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GLI3 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Name: GLI Family Zinc Finger 3
Chromosome: CHR7: 42000547 -42276618
Locus: 7p14.1
CROT Gene Summary
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Gene Name: Carnitine O-octanoyltransferase
Chromosome: CHR7: 86974950 -87029112
Locus: 7q21.12
Gene Diseases
The GLI3 CROT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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