GLI2-SPOP Fusion FISH Probe
The GLI2-SPOP Fusion FISH Probe is used to confirm a fusion of the GLI2 and SPOP genes. The fusion of the GLI2 and SPOP genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLI2-SPOP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-RERE | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-REOR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-REGO | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-REGR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-REAQ | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-ORRE | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-OROR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-ORGO | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GORE | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GOOR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GOGO | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GOGR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GRRE | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GROR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GRGO | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GRGR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-AQRE | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-AQOR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-AQGO | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-AQGR | 20 (40 μL) | 200 μL |
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| GLI2-SPOP-20-AQAQ | 20 (40 μL) | 200 μL |
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GLI2 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Name: GLI Family Zinc Finger 2
Chromosome: CHR2: 121554866 -121750229
Locus: 2q14.2
SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
Gene Diseases
The GLI2 SPOP Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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