GLE1-ODF2 Fusion FISH Probe
The GLE1-ODF2 Fusion FISH Probe is used to confirm a fusion of the GLE1 and ODF2 genes. The fusion of the GLE1 and ODF2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLE1-ODF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-RERE | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-REOR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-REGO | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-REGR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-REAQ | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-ORRE | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-OROR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-ORGO | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GORE | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GOOR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GOGO | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GOGR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GRRE | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GROR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GRGO | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GRGR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-AQRE | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-AQOR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-AQGO | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-AQGR | 20 (40 μL) | 200 μL |
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| GLE1-ODF2-20-AQAQ | 20 (40 μL) | 200 μL |
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GLE1 Gene Summary
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: GLE1, RNA Export Mediator
Chromosome: CHR9: 131266970 -131304580
Locus: 9q34.11
ODF2 Gene Summary
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Gene Name: Outer Dense Fiber Of Sperm Tails 2
Chromosome: CHR9: 131218284 -131263571
Locus: 9q34.11
Gene Diseases
The GLE1 ODF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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