GLA-HNRNPH2 Fusion FISH Probe
The GLA-HNRNPH2 Fusion FISH Probe is used to confirm a fusion of the GLA and HNRNPH2 genes. The fusion of the GLA and HNRNPH2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLA-HNRNPH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-RERE | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-REOR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-REGO | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-REGR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-REAQ | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-ORRE | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-OROR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-ORGO | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GORE | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GOOR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GOGO | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GOGR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GRRE | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GROR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GRGO | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GRGR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-AQRE | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-AQOR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-AQGO | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-AQGR | 20 (40 μL) | 200 μL |
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| GLA-HNRNPH2-20-AQAQ | 20 (40 μL) | 200 μL |
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GLA Gene Summary
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]
Gene Name: Galactosidase Alpha
Chromosome: CHRX: 100652778 -100663001
Locus: Xq22.1
HNRNPH2 Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein H2
Chromosome: CHRX: 100663120 -100669128
Locus: Xq22.1
Gene Diseases
The GLA HNRNPH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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