GJA1-STAT6 Fusion FISH Probe
The GJA1-STAT6 Fusion FISH Probe is used to confirm a fusion of the GJA1 and STAT6 genes. The fusion of the GJA1 and STAT6 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GJA1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| GJA1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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GJA1 Gene Summary
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Gene Name: Gap Junction Protein Alpha 1
Chromosome: CHR6: 121756744 -121770873
Locus: 6q22.31
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The GJA1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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