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GIT2-SMYD5 Fusion FISH Probe

The GIT2-SMYD5 Fusion FISH Probe is used to confirm a fusion of the GIT2 and SMYD5 genes. The fusion of the GIT2 and SMYD5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
GIT2-SMYD5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
GIT2-SMYD5-20-RERE 20 (40 μL) 200 μL
GIT2-SMYD5-20-REOR 20 (40 μL) 200 μL
GIT2-SMYD5-20-REGO 20 (40 μL) 200 μL
GIT2-SMYD5-20-REGR 20 (40 μL) 200 μL
GIT2-SMYD5-20-REAQ 20 (40 μL) 200 μL
GIT2-SMYD5-20-ORRE 20 (40 μL) 200 μL
GIT2-SMYD5-20-OROR 20 (40 μL) 200 μL
GIT2-SMYD5-20-ORGO 20 (40 μL) 200 μL
GIT2-SMYD5-20-ORAQ 20 (40 μL) 200 μL
GIT2-SMYD5-20-GORE 20 (40 μL) 200 μL
GIT2-SMYD5-20-GOOR 20 (40 μL) 200 μL
GIT2-SMYD5-20-GOGO 20 (40 μL) 200 μL
GIT2-SMYD5-20-GOGR 20 (40 μL) 200 μL
GIT2-SMYD5-20-GOAQ 20 (40 μL) 200 μL
GIT2-SMYD5-20-GRRE 20 (40 μL) 200 μL
GIT2-SMYD5-20-GROR 20 (40 μL) 200 μL
GIT2-SMYD5-20-GRGO 20 (40 μL) 200 μL
GIT2-SMYD5-20-GRGR 20 (40 μL) 200 μL
GIT2-SMYD5-20-GRAQ 20 (40 μL) 200 μL
GIT2-SMYD5-20-AQRE 20 (40 μL) 200 μL
GIT2-SMYD5-20-AQOR 20 (40 μL) 200 μL
GIT2-SMYD5-20-AQGO 20 (40 μL) 200 μL
GIT2-SMYD5-20-AQGR 20 (40 μL) 200 μL
GIT2-SMYD5-20-AQAQ 20 (40 μL) 200 μL

GIT2 Gene Summary

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

Gene Name: GIT ArfGAP 2

Chromosome: CHR12: 110367606 -110434194

Locus: 12q24.11

SMYD5 Gene Summary

The SMYD Family Member 5 (SMYD5) gene is located on chr2 :73441365-73454355 at 2p13.2.

Gene Name: SMYD Family Member 5

Chromosome: CHR2: 73441365 -73454355

Locus: 2p13.2

Gene Diseases

The GIT2 SMYD5 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.