GIGYF2-EFHD1 Fusion FISH Probe
The GIGYF2-EFHD1 Fusion FISH Probe is used to confirm a fusion of the GIGYF2 and EFHD1 genes. The fusion of the GIGYF2 and EFHD1 genes has been associated with Lung Squamous Cell Carcinoma, Breast Invasive Carcinoma, Breast Invasive Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GIGYF2-EFHD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-RERE | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-REOR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-REGO | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-REGR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-REAQ | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-ORRE | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-OROR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-ORGO | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GORE | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GOOR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GOGO | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GOGR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GRRE | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GROR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GRGO | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GRGR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-AQRE | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-AQOR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-AQGO | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-AQGR | 20 (40 μL) | 200 μL |
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| GIGYF2-EFHD1-20-AQAQ | 20 (40 μL) | 200 μL |
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GIGYF2 Gene Summary
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: GRB10 Interacting GYF Protein 2
Chromosome: CHR2: 233562014 -233725289
Locus: 2q37.1
EFHD1 Gene Summary
This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Gene Name: EF-hand Domain Family Member D1
Chromosome: CHR2: 233470766 -233547491
Locus: 2q37.1
Gene Diseases
The GIGYF2 EFHD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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