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GIGYF2-EFHD1 Fusion FISH Probe

The GIGYF2-EFHD1 Fusion FISH Probe is used to confirm a fusion of the GIGYF2 and EFHD1 genes. The fusion of the GIGYF2 and EFHD1 genes has been associated with Lung Squamous Cell Carcinoma, Breast Invasive Carcinoma, Breast Invasive Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
GIGYF2-EFHD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-RERE 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-REOR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-REGO 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-REGR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-REAQ 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-ORRE 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-OROR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-ORGO 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-ORAQ 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GORE 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GOOR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GOGO 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GOGR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GOAQ 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GRRE 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GROR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GRGO 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GRGR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-GRAQ 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-AQRE 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-AQOR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-AQGO 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-AQGR 20 (40 μL) 200 μL
GIGYF2-EFHD1-20-AQAQ 20 (40 μL) 200 μL

GIGYF2 Gene Summary

This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Name: GRB10 Interacting GYF Protein 2

Chromosome: CHR2: 233562014 -233725289

Locus: 2q37.1

EFHD1 Gene Summary

This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Gene Name: EF-hand Domain Family Member D1

Chromosome: CHR2: 233470766 -233547491

Locus: 2q37.1

Gene Diseases

The GIGYF2 EFHD1 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma
Breast Invasive Carcinoma
Breast Invasive Carcinoma
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.