GFRA1-DGKB Fusion FISH Probe
The GFRA1-DGKB Fusion FISH Probe is used to confirm a fusion of the GFRA1 and DGKB genes. The fusion of the GFRA1 and DGKB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GFRA1-DGKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-RERE | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-REOR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-REGO | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-REGR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-REAQ | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-ORRE | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-OROR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-ORGO | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GORE | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GOOR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GOGO | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GOGR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GRRE | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GROR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GRGO | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GRGR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-AQRE | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-AQOR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-AQGO | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-AQGR | 20 (40 μL) | 200 μL |
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| GFRA1-DGKB-20-AQAQ | 20 (40 μL) | 200 μL |
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DGKB Gene Summary
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Gene Name: Diacylglycerol Kinase Beta
Chromosome: CHR7: 14184673 -14881075
Locus: 7p21.2
GFRA1 Gene Summary
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: GDNF Family Receptor Alpha 1
Chromosome: CHR10: 117816441 -118033126
Locus: 10q25.3
Gene Diseases
The GFRA1 DGKB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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