GDNF-FYB Fusion FISH Probe
The GDNF-FYB Fusion FISH Probe is used to confirm a fusion of the GDNF and FYB genes. The fusion of the GDNF and FYB genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GDNF-FYB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-RERE | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-REOR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-REGO | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-REGR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-REAQ | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-ORRE | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-OROR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-ORGO | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-ORAQ | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GORE | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GOOR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GOGO | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GOGR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GOAQ | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GRRE | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GROR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GRGO | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GRGR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-GRAQ | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-AQRE | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-AQOR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-AQGO | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-AQGR | 20 (40 μL) | 200 μL |
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| GDNF-FYB-20-AQAQ | 20 (40 μL) | 200 μL |
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GDNF Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Gene Name: Glial Cell Derived Neurotrophic Factor
Chromosome: CHR5: 37812778 -37839782
Locus: 5p13.2
Gene Diseases
The GDNF FYB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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