GDI2-IL2RA Fusion FISH Probe
The GDI2-IL2RA Fusion FISH Probe is used to confirm a fusion of the GDI2 and IL2RA genes. The fusion of the GDI2 and IL2RA genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GDI2-IL2RA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| GDI2-IL2RA-20-AQAQ | 20 (40 μL) | 200 μL |
|
GDI2 Gene Summary
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: GDP Dissociation Inhibitor 2
Chromosome: CHR10: 5807185 -5855512
Locus: 10p15.1
IL2RA Gene Summary
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Gene Name: Interleukin 2 Receptor Subunit Alpha
Chromosome: CHR10: 6052656 -6104333
Locus: 10p15.1
Gene Diseases
The GDI2 IL2RA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|