GDF11-HOXC8 Fusion FISH Probe
The GDF11-HOXC8 Fusion FISH Probe is used to confirm a fusion of the GDF11 and HOXC8 genes. The fusion of the GDF11 and HOXC8 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GDF11-HOXC8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-RERE | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-REOR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-REGO | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-REGR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-REAQ | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-ORRE | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-OROR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-ORGO | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-ORAQ | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GORE | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GOOR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GOGO | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GOGR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GOAQ | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GRRE | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GROR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GRGO | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GRGR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-GRAQ | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-AQRE | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-AQOR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-AQGO | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-AQGR | 20 (40 μL) | 200 μL |
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| GDF11-HOXC8-20-AQAQ | 20 (40 μL) | 200 μL |
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HOXC8 Gene Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
Gene Name: Homeobox C8
Chromosome: CHR12: 54402889 -54406545
Locus: 12q13.13
GDF11 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
Gene Name: Growth Differentiation Factor 11
Chromosome: CHR12: 56137063 -56146665
Locus: 12q13.2
Gene Diseases
The GDF11 HOXC8 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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