GCN1L1-CCND2 Fusion FISH Probe
The GCN1L1-CCND2 Fusion FISH Probe is used to confirm a fusion of the GCN1L1 and CCND2 genes. The fusion of the GCN1L1 and CCND2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GCN1L1-CCND2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-RERE | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-REOR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-REGO | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-REGR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-REAQ | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-ORRE | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-OROR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-ORGO | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GORE | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GOOR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GOGO | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GOGR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GRRE | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GROR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GRGO | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GRGR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-AQRE | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-AQOR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-AQGO | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-AQGR | 20 (40 μL) | 200 μL |
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| GCN1L1-CCND2-20-AQAQ | 20 (40 μL) | 200 μL |
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CCND2 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Gene Name: Cyclin D2
Chromosome: CHR12: 4382901 -4414522
Locus: 12p13.32
Gene Diseases
The GCN1L1 CCND2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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