GBA2-ATP6V1C1 Fusion FISH Probe
The GBA2-ATP6V1C1 Fusion FISH Probe is used to confirm a fusion of the GBA2 and ATP6V1C1 genes. The fusion of the GBA2 and ATP6V1C1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GBA2-ATP6V1C1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-RERE | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-REOR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-REGO | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-REGR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-REAQ | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-ORRE | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-OROR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-ORGO | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GORE | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GOOR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GOGO | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GOGR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GRRE | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GROR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GRGO | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GRGR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-AQRE | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-AQOR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-AQGO | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-AQGR | 20 (40 μL) | 200 μL |
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| GBA2-ATP6V1C1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V1C1 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V1 Subunit C1
Chromosome: CHR8: 104033247 -104085285
Locus: 8q22.3
GBA2 Gene Summary
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008]
Gene Name: Glucosylceramidase Beta 2
Chromosome: CHR9: 35736862 -35749225
Locus: 9p13.3
Gene Diseases
The GBA2 ATP6V1C1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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