GAN-GRM7 Fusion FISH Probe
The GAN-GRM7 Fusion FISH Probe is used to confirm a fusion of the GAN and GRM7 genes. The fusion of the GAN and GRM7 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAN-GRM7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-RERE | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-REOR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-REGO | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-REGR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-REAQ | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-ORRE | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-OROR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-ORGO | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GORE | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GOOR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GOGO | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GOGR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GRRE | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GROR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GRGO | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GRGR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-AQRE | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-AQOR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-AQGO | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-AQGR | 20 (40 μL) | 200 μL |
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| GAN-GRM7-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM7 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Name: Glutamate Metabotropic Receptor 7
Chromosome: CHR3: 6902801 -7783218
Locus: 3p26.1
GAN Gene Summary
This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
Gene Name: Gigaxonin
Chromosome: CHR16: 81348570 -81413803
Locus: 16q23.2
Gene Diseases
The GAN GRM7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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