GAK-SPON2 Fusion FISH Probe
The GAK-SPON2 Fusion FISH Probe is used to confirm a fusion of the GAK and SPON2 genes. The fusion of the GAK and SPON2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAK-SPON2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-RERE | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-REOR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-REGO | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-REGR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-REAQ | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-ORRE | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-OROR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-ORGO | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GORE | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GOOR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GOGO | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GOGR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GRRE | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GROR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GRGO | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GRGR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-AQRE | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-AQOR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-AQGO | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-AQGR | 20 (40 μL) | 200 μL |
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| GAK-SPON2-20-AQAQ | 20 (40 μL) | 200 μL |
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GAK Gene Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Cyclin G Associated Kinase
Chromosome: CHR4: 843064 -926174
Locus: 4p16.3
SPON2 Gene Summary
The Spondin 2 (SPON2) gene is located on chr4 :1160720-1202750 at 4p16.3.
Gene Name: Spondin 2
Chromosome: CHR4: 1160720 -1202750
Locus: 4p16.3
Gene Diseases
The GAK SPON2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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