GAK-MAGI1 Fusion FISH Probe
The GAK-MAGI1 Fusion FISH Probe is used to confirm a fusion of the GAK and MAGI1 genes. The fusion of the GAK and MAGI1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAK-MAGI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-RERE | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-REOR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-REGO | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-REGR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-REAQ | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-ORRE | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-OROR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-ORGO | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GORE | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GOOR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GOGO | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GOGR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GRRE | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GROR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GRGO | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GRGR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-AQRE | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-AQOR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-AQGO | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-AQGR | 20 (40 μL) | 200 μL |
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| GAK-MAGI1-20-AQAQ | 20 (40 μL) | 200 μL |
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GAK Gene Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Cyclin G Associated Kinase
Chromosome: CHR4: 843064 -926174
Locus: 4p16.3
MAGI1 Gene Summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1
Chromosome: CHR3: 65339905 -66024509
Locus: 3p14.1
Gene Diseases
The GAK MAGI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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