GAK-LUC7L3 Fusion FISH Probe
The GAK-LUC7L3 Fusion FISH Probe is used to confirm a fusion of the GAK and LUC7L3 genes. The fusion of the GAK and LUC7L3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAK-LUC7L3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-RERE | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-REOR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-REGO | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-REGR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-REAQ | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-ORRE | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-OROR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-ORGO | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GORE | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GOOR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GOGO | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GOGR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GRRE | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GROR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GRGO | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GRGR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-AQRE | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-AQOR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-AQGO | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-AQGR | 20 (40 μL) | 200 μL |
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| GAK-LUC7L3-20-AQAQ | 20 (40 μL) | 200 μL |
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GAK Gene Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Cyclin G Associated Kinase
Chromosome: CHR4: 843064 -926174
Locus: 4p16.3
LUC7L3 Gene Summary
This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Name: LUC7 Like 3 Pre-mRNA Splicing Factor
Chromosome: CHR17: 48796925 -48830072
Locus: 17q21.33
Gene Diseases
The GAK LUC7L3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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