GABRG3-OCA2 Fusion FISH Probe
The GABRG3-OCA2 Fusion FISH Probe is used to confirm a fusion of the GABRG3 and OCA2 genes. The fusion of the GABRG3 and OCA2 genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GABRG3-OCA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-RERE | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-REOR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-REGO | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-REGR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-REAQ | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-ORRE | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-OROR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-ORGO | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GORE | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GOOR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GOGO | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GOGR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GRRE | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GROR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GRGO | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GRGR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-AQRE | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-AQOR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-AQGO | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-AQGR | 20 (40 μL) | 200 μL |
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| GABRG3-OCA2-20-AQAQ | 20 (40 μL) | 200 μL |
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GABRG3 Gene Summary
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Name: Gamma-aminobutyric Acid Type A Receptor Gamma3 Subunit
Chromosome: CHR15: 27216428 -27778373
Locus: 15q12
OCA2 Gene Summary
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: OCA2 Melanosomal Transmembrane Protein
Chromosome: CHR15: 28000022 -28344458
Locus: 15q12-q13.1
Gene Diseases
The GABRG3 OCA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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