GABRB3-TJP1 Fusion FISH Probe
The GABRB3-TJP1 Fusion FISH Probe is used to confirm a fusion of the GABRB3 and TJP1 genes. The fusion of the GABRB3 and TJP1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GABRB3-TJP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-RERE | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-REOR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-REGO | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-REGR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-REAQ | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-ORRE | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-OROR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-ORGO | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GORE | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GOOR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GOGO | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GOGR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GRRE | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GROR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GRGO | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GRGR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-AQRE | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-AQOR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-AQGO | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-AQGR | 20 (40 μL) | 200 μL |
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| GABRB3-TJP1-20-AQAQ | 20 (40 μL) | 200 μL |
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GABRB3 Gene Summary
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Name: Gamma-aminobutyric Acid Type A Receptor Beta3 Subunit
Chromosome: CHR15: 26788693 -27018935
Locus: 15q12
TJP1 Gene Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tight Junction Protein 1
Chromosome: CHR15: 29992356 -30114706
Locus: 15q13.1
Gene Diseases
The GABRB3 TJP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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