GAB2-TRIP12 Fusion FISH Probe
The GAB2-TRIP12 Fusion FISH Probe is used to confirm a fusion of the GAB2 and TRIP12 genes. The fusion of the GAB2 and TRIP12 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAB2-TRIP12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-RERE | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-REOR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-REGO | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-REGR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-REAQ | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-ORRE | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-OROR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-ORGO | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GORE | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GOOR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GOGO | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GOGR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GRRE | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GROR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GRGO | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GRGR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-AQRE | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-AQOR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-AQGO | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-AQGR | 20 (40 μL) | 200 μL |
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| GAB2-TRIP12-20-AQAQ | 20 (40 μL) | 200 μL |
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TRIP12 Gene Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
Gene Name: Thyroid Hormone Receptor Interactor 12
Chromosome: CHR2: 230631929 -230786655
Locus: 2q36.3
GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
Gene Diseases
The GAB2 TRIP12 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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