GAB2-PTPRT Fusion FISH Probe
The GAB2-PTPRT Fusion FISH Probe is used to confirm a fusion of the GAB2 and PTPRT genes. The fusion of the GAB2 and PTPRT genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAB2-PTPRT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-RERE | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-REOR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-REGO | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-REGR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-REAQ | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-ORRE | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-OROR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-ORGO | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GORE | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GOOR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GOGO | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GOGR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GRRE | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GROR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GRGO | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GRGR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-AQRE | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-AQOR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-AQGO | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-AQGR | 20 (40 μL) | 200 μL |
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| GAB2-PTPRT-20-AQAQ | 20 (40 μL) | 200 μL |
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GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
PTPRT Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type T
Chromosome: CHR20: 40701391 -41818557
Locus: 20q12-q13.11
Gene Diseases
The GAB2 PTPRT Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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