GAB2-FGF7 Fusion FISH Probe
The GAB2-FGF7 Fusion FISH Probe is used to confirm a fusion of the GAB2 and FGF7 genes. The fusion of the GAB2 and FGF7 genes has been associated with Skin Cutaneous Melanoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAB2-FGF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-RERE | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-REOR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-REGO | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-REGR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-REAQ | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-ORRE | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-OROR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-ORGO | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GORE | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GOOR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GOGO | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GOGR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GRRE | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GROR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GRGO | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GRGR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-AQRE | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-AQOR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-AQGO | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-AQGR | 20 (40 μL) | 200 μL |
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| GAB2-FGF7-20-AQAQ | 20 (40 μL) | 200 μL |
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FGF7 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 7
Chromosome: CHR15: 49715374 -49779523
Locus: 15q21.2
GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
Gene Diseases
The GAB2 FGF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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