G6PD-F8 Fusion FISH Probe
The G6PD-F8 Fusion FISH Probe is used to confirm a fusion of the G6PD and F8 genes. The fusion of the G6PD and F8 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| G6PD-F8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-RERE | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-REOR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-REGO | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-REGR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-REAQ | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-ORRE | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-OROR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-ORGO | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-ORAQ | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GORE | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GOOR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GOGO | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GOGR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GOAQ | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GRRE | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GROR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GRGO | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GRGR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-GRAQ | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-AQRE | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-AQOR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-AQGO | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-AQGR | 20 (40 μL) | 200 μL |
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| G6PD-F8-20-AQAQ | 20 (40 μL) | 200 μL |
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F8 Gene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor VIII
Chromosome: CHRX: 154064063 -154250998
Locus: Xq28
G6PD Gene Summary
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glucose-6-phosphate Dehydrogenase
Chromosome: CHRX: 153759605 -153775787
Locus: Xq28
Gene Diseases
The G6PD F8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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