FZD6-DPYS Fusion FISH Probe
The FZD6-DPYS Fusion FISH Probe is used to confirm a fusion of the FZD6 and DPYS genes. The fusion of the FZD6 and DPYS genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FZD6-DPYS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-RERE | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-REOR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-REGO | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-REGR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-REAQ | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-ORRE | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-OROR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-ORGO | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-ORAQ | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GORE | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GOOR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GOGO | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GOGR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GOAQ | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GRRE | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GROR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GRGO | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GRGR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-GRAQ | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-AQRE | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-AQOR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-AQGO | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-AQGR | 20 (40 μL) | 200 μL |
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| FZD6-DPYS-20-AQAQ | 20 (40 μL) | 200 μL |
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DPYS Gene Summary
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Gene Name: Dihydropyrimidinase
Chromosome: CHR8: 105391651 -105479277
Locus: 8q22.3
FZD6 Gene Summary
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Gene Name: Frizzled Class Receptor 6
Chromosome: CHR8: 104310660 -104345094
Locus: 8q22.3
Gene Diseases
The FZD6 DPYS Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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