FYCO1-ATG7 Fusion FISH Probe
The FYCO1-ATG7 Fusion FISH Probe is used to confirm a fusion of the FYCO1 and ATG7 genes. The fusion of the FYCO1 and ATG7 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FYCO1-ATG7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-RERE | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-REOR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-REGO | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-REGR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-REAQ | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-ORRE | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-OROR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-ORGO | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-ORAQ | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GORE | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GOOR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GOGO | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GOGR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GOAQ | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GRRE | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GROR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GRGO | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GRGR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-GRAQ | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-AQRE | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-AQOR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-AQGO | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-AQGR | 20 (40 μL) | 200 μL |
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| FYCO1-ATG7-20-AQAQ | 20 (40 μL) | 200 μL |
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ATG7 Gene Summary
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: Autophagy Related 7
Chromosome: CHR3: 11314009 -11599139
Locus: 3p25.3
FYCO1 Gene Summary
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
Gene Name: FYVE And Coiled-coil Domain Containing 1
Chromosome: CHR3: 45959394 -46037307
Locus: 3p21.31
Gene Diseases
The FYCO1 ATG7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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