FXR2-TP53 Fusion FISH Probe
The FXR2-TP53 Fusion FISH Probe is used to confirm a fusion of the FXR2 and TP53 genes. The fusion of the FXR2 and TP53 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FXR2-TP53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FXR2-TP53-20-AQAQ | 20 (40 μL) | 200 μL |
|
TP53 Gene Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Gene Name: Tumor Protein P53
Chromosome: CHR17: 7571719 -7590863
Locus: 17p13.1
FXR2 Gene Summary
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]
Gene Name: FMR1 Autosomal Homolog 2
Chromosome: CHR17: 7494547 -7518215
Locus: 17p13.1
Gene Diseases
The FXR2 TP53 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|