FXR1-MCCC1 Fusion FISH Probe
The FXR1-MCCC1 Fusion FISH Probe is used to confirm a fusion of the FXR1 and MCCC1 genes. The fusion of the FXR1 and MCCC1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FXR1-MCCC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-RERE | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-REOR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-REGO | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-REGR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-REAQ | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-ORRE | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-OROR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-ORGO | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GORE | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GOOR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GOGO | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GOGR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GRRE | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GROR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GRGO | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GRGR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-AQRE | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-AQOR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-AQGO | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-AQGR | 20 (40 μL) | 200 μL |
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| FXR1-MCCC1-20-AQAQ | 20 (40 μL) | 200 μL |
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FXR1 Gene Summary
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: FMR1 Autosomal Homolog 1
Chromosome: CHR3: 180630233 -180700539
Locus: 3q26.33
MCCC1 Gene Summary
This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]
Gene Name: Methylcrotonoyl-CoA Carboxylase 1
Chromosome: CHR3: 182733005 -182817365
Locus: 3q27.1
Gene Diseases
The FXR1 MCCC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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