FUS-DDIT3 Fusion FISH Probe
The FUS-DDIT3 Fusion FISH Probe is used to confirm a fusion of the FUS and DDIT3 genes. The fusion of the FUS and DDIT3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FUS-DDIT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-RERE | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-REOR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-REGO | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-REGR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-REAQ | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-ORRE | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-OROR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-ORGO | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GORE | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GOOR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GOGO | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GOGR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GRRE | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GROR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GRGO | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GRGR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-AQRE | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-AQOR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-AQGO | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-AQGR | 20 (40 μL) | 200 μL |
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| FUS-DDIT3-20-AQAQ | 20 (40 μL) | 200 μL |
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DDIT3 Gene Summary
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Gene Name: DNA Damage Inducible Transcript 3
Chromosome: CHR12: 57910370 -57914300
Locus: 12q13.3
FUS Gene Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Gene Name: FUS RNA Binding Protein
Chromosome: CHR16: 31191430 -31206192
Locus: 16p11.2
Gene Diseases
The FUS DDIT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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