FUK-PDPR Fusion FISH Probe
The FUK-PDPR Fusion FISH Probe is used to confirm a fusion of the FUK and PDPR genes. The fusion of the FUK and PDPR genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FUK-PDPR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-RERE | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-REOR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-REGO | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-REGR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-REAQ | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-ORRE | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-OROR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-ORGO | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-ORAQ | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GORE | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GOOR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GOGO | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GOGR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GOAQ | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GRRE | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GROR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GRGO | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GRGR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-GRAQ | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-AQRE | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-AQOR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-AQGO | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-AQGR | 20 (40 μL) | 200 μL |
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| FUK-PDPR-20-AQAQ | 20 (40 μL) | 200 μL |
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PDPR Gene Summary
Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Pyruvate Dehydrogenase Phosphatase Regulatory Subunit
Chromosome: CHR16: 70147528 -70195184
Locus: 16q22.1
FUK Gene Summary
The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]
Gene Name: Fucokinase
Chromosome: CHR16: 70488497 -70514177
Locus: 16q22.1
Gene Diseases
The FUK PDPR Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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