FUBP1-DNAJB4 Fusion FISH Probe
The FUBP1-DNAJB4 Fusion FISH Probe is used to confirm a fusion of the FUBP1 and DNAJB4 genes. The fusion of the FUBP1 and DNAJB4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FUBP1-DNAJB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-RERE | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-REOR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-REGO | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-REGR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-REAQ | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-ORRE | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-OROR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-ORGO | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GORE | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GOOR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GOGO | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GOGR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GRRE | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GROR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GRGO | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GRGR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-AQRE | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-AQOR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-AQGO | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-AQGR | 20 (40 μL) | 200 μL |
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| FUBP1-DNAJB4-20-AQAQ | 20 (40 μL) | 200 μL |
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FUBP1 Gene Summary
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Far Upstream Element Binding Protein 1
Chromosome: CHR1: 78413590 -78444777
Locus: 1p31.1
DNAJB4 Gene Summary
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member B4
Chromosome: CHR1: 78470635 -78482995
Locus: 1p31.1
Gene Diseases
The FUBP1 DNAJB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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