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FUBP1-DNAJB4 Fusion FISH Probe

The FUBP1-DNAJB4 Fusion FISH Probe is used to confirm a fusion of the FUBP1 and DNAJB4 genes. The fusion of the FUBP1 and DNAJB4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FUBP1-DNAJB4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-RERE 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-REOR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-REGO 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-REGR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-REAQ 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-ORRE 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-OROR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-ORGO 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-ORAQ 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GORE 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GOOR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GOGO 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GOGR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GOAQ 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GRRE 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GROR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GRGO 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GRGR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-GRAQ 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-AQRE 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-AQOR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-AQGO 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-AQGR 20 (40 μL) 200 μL
FUBP1-DNAJB4-20-AQAQ 20 (40 μL) 200 μL

FUBP1 Gene Summary

The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Gene Name: Far Upstream Element Binding Protein 1

Chromosome: CHR1: 78413590 -78444777

Locus: 1p31.1

DNAJB4 Gene Summary

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member B4

Chromosome: CHR1: 78470635 -78482995

Locus: 1p31.1

Gene Diseases

The FUBP1 DNAJB4 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.