FSCN1-FAR1 Fusion FISH Probe
The FSCN1-FAR1 Fusion FISH Probe is used to confirm a fusion of the FSCN1 and FAR1 genes. The fusion of the FSCN1 and FAR1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FSCN1-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| FSCN1-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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FSCN1 Gene Summary
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Gene Name: Fascin Actin-bundling Protein 1
Chromosome: CHR7: 5632453 -5646286
Locus: 7p22.1
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The FSCN1 FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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