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FSCN1-FAR1 Fusion FISH Probe

The FSCN1-FAR1 Fusion FISH Probe is used to confirm a fusion of the FSCN1 and FAR1 genes. The fusion of the FSCN1 and FAR1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FSCN1-FAR1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FSCN1-FAR1-20-RERE 20 (40 μL) 200 μL
FSCN1-FAR1-20-REOR 20 (40 μL) 200 μL
FSCN1-FAR1-20-REGO 20 (40 μL) 200 μL
FSCN1-FAR1-20-REGR 20 (40 μL) 200 μL
FSCN1-FAR1-20-REAQ 20 (40 μL) 200 μL
FSCN1-FAR1-20-ORRE 20 (40 μL) 200 μL
FSCN1-FAR1-20-OROR 20 (40 μL) 200 μL
FSCN1-FAR1-20-ORGO 20 (40 μL) 200 μL
FSCN1-FAR1-20-ORAQ 20 (40 μL) 200 μL
FSCN1-FAR1-20-GORE 20 (40 μL) 200 μL
FSCN1-FAR1-20-GOOR 20 (40 μL) 200 μL
FSCN1-FAR1-20-GOGO 20 (40 μL) 200 μL
FSCN1-FAR1-20-GOGR 20 (40 μL) 200 μL
FSCN1-FAR1-20-GOAQ 20 (40 μL) 200 μL
FSCN1-FAR1-20-GRRE 20 (40 μL) 200 μL
FSCN1-FAR1-20-GROR 20 (40 μL) 200 μL
FSCN1-FAR1-20-GRGO 20 (40 μL) 200 μL
FSCN1-FAR1-20-GRGR 20 (40 μL) 200 μL
FSCN1-FAR1-20-GRAQ 20 (40 μL) 200 μL
FSCN1-FAR1-20-AQRE 20 (40 μL) 200 μL
FSCN1-FAR1-20-AQOR 20 (40 μL) 200 μL
FSCN1-FAR1-20-AQGO 20 (40 μL) 200 μL
FSCN1-FAR1-20-AQGR 20 (40 μL) 200 μL
FSCN1-FAR1-20-AQAQ 20 (40 μL) 200 μL

FSCN1 Gene Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Gene Name: Fascin Actin-bundling Protein 1

Chromosome: CHR7: 5632453 -5646286

Locus: 7p22.1

FAR1 Gene Summary

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]

Gene Name: Fatty Acyl-CoA Reductase 1

Chromosome: CHR11: 13690205 -13753893

Locus: 11p15.3

Gene Diseases

The FSCN1 FAR1 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.