FSCN1-EIF2AK1 Fusion FISH Probe
The FSCN1-EIF2AK1 Fusion FISH Probe is used to confirm a fusion of the FSCN1 and EIF2AK1 genes. The fusion of the FSCN1 and EIF2AK1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FSCN1-EIF2AK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-RERE | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-REOR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-REGO | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-REGR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-REAQ | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-ORRE | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-OROR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-ORGO | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GORE | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GOOR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GOGO | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GOGR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GRRE | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GROR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GRGO | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GRGR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-AQRE | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-AQOR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-AQGO | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-AQGR | 20 (40 μL) | 200 μL |
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| FSCN1-EIF2AK1-20-AQAQ | 20 (40 μL) | 200 μL |
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FSCN1 Gene Summary
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Gene Name: Fascin Actin-bundling Protein 1
Chromosome: CHR7: 5632453 -5646286
Locus: 7p22.1
EIF2AK1 Gene Summary
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1
Chromosome: CHR7: 6061877 -6098860
Locus: 7p22.1
Gene Diseases
The FSCN1 EIF2AK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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