FRS2-NRG3 Fusion FISH Probe
The FRS2-NRG3 Fusion FISH Probe is used to confirm a fusion of the FRS2 and NRG3 genes. The fusion of the FRS2 and NRG3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FRS2-NRG3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-RERE | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-REOR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-REGO | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-REGR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-REAQ | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-ORRE | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-OROR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-ORGO | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GORE | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GOOR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GOGO | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GOGR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GRRE | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GROR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GRGO | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GRGR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-AQRE | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-AQOR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-AQGO | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-AQGR | 20 (40 μL) | 200 μL |
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| FRS2-NRG3-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG3 Gene Summary
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Gene Name: Neuregulin 3
Chromosome: CHR10: 83635069 -84746935
Locus: 10q23.1
FRS2 Gene Summary
The Fibroblast Growth Factor Receptor Substrate 2 (FRS2) gene is located on chr12 :69864128-69973562 at 12q15.
Gene Name: Fibroblast Growth Factor Receptor Substrate 2
Chromosome: CHR12: 69864128 -69973562
Locus: 12q15
Gene Diseases
The FRS2 NRG3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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