FRAS1-MGMT Fusion FISH Probe
The FRAS1-MGMT Fusion FISH Probe is used to confirm a fusion of the FRAS1 and MGMT genes. The fusion of the FRAS1 and MGMT genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FRAS1-MGMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-RERE | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-REOR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-REGO | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-REGR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-REAQ | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-ORRE | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-OROR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-ORGO | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GORE | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GOOR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GOGO | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GOGR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GRRE | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GROR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GRGO | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GRGR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-AQRE | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-AQOR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-AQGO | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-AQGR | 20 (40 μL) | 200 μL |
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| FRAS1-MGMT-20-AQAQ | 20 (40 μL) | 200 μL |
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MGMT Gene Summary
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Gene Name: O-6-methylguanine-DNA Methyltransferase
Chromosome: CHR10: 131265453 -131565783
Locus: 10q26.3
FRAS1 Gene Summary
This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Name: Fraser Extracellular Matrix Complex Subunit 1
Chromosome: CHR4: 78978723 -79465423
Locus: 4q21.21
Gene Diseases
The FRAS1 MGMT Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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